Lung Cancer | Oncology Today with Dr Neil Love: Current and Emerging Strategies for Patients with Non-Small Cell Lung Cancer Harboring an EGFR Exon 20 Insertion Mutation

published 4 months ago by Dr Neil Love

Featuring an interview with Dr Zofia Piotrowska on the following topics: Current and emerging strategies for patients with non-small cell lung cancer (NSCLC) harboring an EGFR exon 20 insertion mutation (0:00) Case: A woman in her mid-50s with metastatic NSCLC and an EGFR exon 20 insertion receives mobocertinib as second-line therapy on a clinical trial (16:40) Case: A man in his late 60s with advanced NSCLC and an EGFR exon 20 insertion receives amivantamab as second-line therapy (21:11) Activity of mobocertinib in patients with advanced NSCLC and EGFR exon 20 insertions in the first-line setting; mechanism of action of amivantamab, a bispecific antibody targeting EGFR and MET (23:47) Cardiac toxicities associated with EGFR tyrosine kinase inhibitors (27:29) Efficacy of osimertinib in patients with NSCLC and EGFR exon 20 insertions (29:48) Therapeutic approach for patients with NSCLC and HER2 alterations (32:10) Role of immune checkpoint inhibitors for patients with NSCLC and targetable mutations (37:36) Management of NSCLC in patients with actionable alterations who develop brain metastases (41:33) Development of resistance in patients with NSCLC and targetable alterations; use of liquid biopsies for monitoring patients (44:37) EGFR-mutated adenocarcinomas that transform to small-cell lung cancer and other neuroendocrine carcinomas (47:18) Adjuvant therapy for patients with NSCLC and targetable mutations (51:01) Therapeutic approach for patients with locally advanced unresectable NSCLC and EGFR mutations (56:25) Potentiation of the risk of immune-related adverse events in patients receiving immunotherapy followed by osimertinib (59:00) Perspective on COVID-19 vaccination for patients with lung cancer; experience caring for patients with COVID-19 (1:04:11) CME information and select publications

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