Melanoma | Michael A Davies, MD, PhD

published 5 months ago by Dr Neil Love

Melanoma Update, Issue 1, 2021 — Part 1: Our interview with Dr Davies highlights the following topics as well as cases from his practice: Evolving treatment approaches for regionally metastatic melanoma (0:00) Case: A man in his early 70s with a history of poorly controlled hypertension who is diagnosed with Stage IIIB melanoma with a BRAF V600E mutation (20:42) Case: A woman in her mid-20s with Stage IIIA melanoma with a BRAF V600E mutation (28:46) Case: A man in his early 30s with Stage IIIC melanoma and an NRAS Q61K mutation (37:53) Role of immunotherapy for patients with melanoma in the adjuvant setting (44:16) Adjuvant therapy with BRAF/MEK inhibitors for patients with melanoma and BRAF mutations (48:51) Design and results of the Phase III KEYNOTE-054 trial comparing pembrolizumab to placebo after complete resection of high-risk Stage III melanoma (50:58) Benefits and risks of adjuvant immunotherapy and targeted therapy (53:06) Risk of brain metastases for patients with melanoma; efficacy of nivolumab/ipilimumab in patients with brain metastases (57:16) Activity and tolerability of dabrafenib/trametinib as adjuvant therapy (1:01:38) Emerging data with targeted therapy and immunotherapy in the neoadjuvant setting (1:08:45) Role of immunotherapy and targeted therapy for mucosal and uveal melanoma; improvement in overall survival with the novel bispecific fusion protein tebentafusp for metastatic uveal melanoma (1:13:57) Efficacy of autologous tumor infiltrating lymphocytes (TILs) for patients with metastatic melanoma (1:16:54) Approach to relapse after immunotherapy or targeted therapy in the adjuvant setting (1:19:43) Emerging data from the Phase III CheckMate 915 trial of nivolumab alone or with ipilimumab for patients with resected high-risk melanoma; results of the CheckMate 067 trial of nivolumab or ipilimumab alone or in combination for advanced melanoma (1:23:15) CME information and select publications

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