Amyloid Light Chain Amyloidosis | Oncology Today with Dr Neil Love: Advances in the Management of Amyloid Light Chain Amyloidosis

published 4 months ago by Dr Neil Love

Featuring an interview with Dr Morie A Gertz, including the following topics: Recent advances in the treatment of amyloid light chain (AL) amyloidosis (0:00) Case: A woman in her late 70s receiving medical care for monoclonal gammopathy of undetermined significance (MGUS) is diagnosed with AL amyloidosis (22:12) Case: A man in his late 70s being monitored for multiple myeloma after a diagnosis of smoldering multiple myeloma is found to have AL amyloidosis (25:04) Case: A man in his early 70s with amyloidosis with peripheral neuropathy receives a misdiagnosis of MGUS (26:29) Pathophysiology and diagnosis of AL amyloidosis (28:32) Case: A woman in her late 70s being monitored for MGUS is found to have AL amyloidosis (34:37) Design, eligibility criteria and key endpoints of the Phase III ANDROMEDA study evaluating subcutaneous daratumumab in combination with CyBorD versus CyBorD alone for patients with newly diagnosed AL amyloidosis (39:22) Activity and tolerability of pomalidomide, venetoclax or isatuximab in patients with AL amyloidosis (47:48) Mechanism of action and efficacy of CAEL-101, an antibody targeting light chain amyloid fibrils, for AL amyloidosis (53:48) Selection and sequencing of therapy for patients with AL amyloidosis (56:17) CME information and select publications

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