Prostate Cancer | Charles J Ryan, MD

published 4 months ago by Dr Neil Love

Prostate Cancer Update, Issue 2, 2021 — Part 1: Our interview with Dr Ryan highlights the following topics as well as cases from his practice: Practical factors influencing the selection of therapy for patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC) (0:00) Case: A man in his late 60s with nmCRPC receives first-line therapy with abiraterone (29:53) Case: A man with CRPC and high microsatellite instability attains a dramatic response to pembrolizumab (37:31) Perspective on the use of adjuvant radiation and salvage radiation therapy for patients with prostate cancer (46:10) PSMA (prostate-specific membrane antigen)-targeted PET scanning in prostate cancer; therapeutic approach to M0 disease in patients who experience disease progression on androgen deprivation therapy (48:49) Benefits of early initiation of secondary hormonal therapy (57:06) Counseling patients about therapeutic options for mHSPC; considerations for clinical care in the COVID-19 era (1:01:08) Choice of secondary hormonal therapy for patients with metastatic prostate cancer (1:09:21) Selection and sequencing of therapy for patients with mCRPC (1:12:03) Management of disease that progresses on androgen receptor (AR)-targeted therapy; CARD trial of cabazitaxel versus AR-targeted agents for patients with previously treated mCRPC (1:16:34) Role of chemotherapy and PARP inhibitors for patients with prostate cancer and DNA damage repair gene alterations (1:20:02) CME information and select publications

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