Ovarian Cancer | Oncology Today with Dr Neil Love: The Evolving Role of PARP Inhibition in the Management of Ovarian Cancer

published 1 month ago by Dr Neil Love

Featuring an interview with Dr Shannon N Westin on the following topics: Evolving role of PARP inhibition in the management of ovarian cancer (OC) (0:00) Frequency and clinical significance of germline and somatic BRCA mutations and other genomic signatures that may predict benefit from PARP inhibition (3:46) Pivotal Phase III trials of PARP inhibitors alone or in combination with bevacizumab as maintenance therapy for patients with newly diagnosed OC (8:51) Approaches to overcoming PARP inhibitor resistance; PARP inhibitors in combination with immune checkpoint inhibitors (17:56) Novel immune checkpoint inhibitor-based regimens under investigation in OC (25:15) Case: A woman in her early 40s with newly diagnosed high-grade serous OC with a somatic BRCA mutation (28:03) Integration of maintenance PARP inhibition alone or in combination with bevacizumab into the management of newly diagnosed OC (33:32) Duration of PARP inhibitor maintenance therapy; clinical management of common treatment-associated side effects (38:19) Case: A woman in her mid-60s with newly diagnosed Stage IV high-grade serous OC with evidence of genomic instability on her homologous recombination deficiency test (43:09) Activity and tolerability of olaparib/bevacizumab as maintenance therapy (51:14) Case: A woman in her early 50s with newly diagnosed Stage IV homologous recombination-proficient OC (58:53) CME information and select publications

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