Acute Myeloid Leukemia | Daniel A Pollyea, MD, MS

published 6 days ago by Dr Neil Love

A special video supplement to a CME conference held during the 61st ASH Annual Meeting featuring expert comments on the management of acute myeloid leukemia. Featuring perspectives from Dr Daniel A Pollyea. Choice of first-line therapy for acute myeloid leukemia (AML); selection of patients who are fit for intensive chemotherapy (00:00) Perspective on the choice of hypomethylating agent (HMA) to combine with venetoclax (04:03) Clinical implications of the Phase III QUAZAR AML-001 study assessing maintenance CC-486 for patients with AML in first remission (06:46) Potential implications of combining CC-486 with venetoclax for AML (10:25) Biologic rationale for the synergistic effect of venetoclax with an HMA or low-dose cytarabine for patients with AML (13:24) Identifying nonresponders to venetoclax-based combination therapy; managing the monocytic (FABM5) subgroup of AML (17:00) Rationale for combining venetoclax with azacitidine; optimal duration of HMA therapy (20:13) Monitoring bone marrow counts in patients with AML receiving venetoclax-based therapy; role of dose interruptions in managing cytopenias (23:32) Effect of venetoclax-based combinations on extramedullary disease (27:36) Strategies to mitigate tumor lysis syndrome associated with venetoclax-based therapy (28:38) Perspective on the use of prophylaxis to reduce the risk of infections associated with venetoclax (30:26) Recommendations for hospitalization of patients with AML receiving venetoclax-based therapies (33:07) Use of venetoclax/HMA therapy in patients with AML and high white blood cell counts (35:41) Benefit with the addition of venetoclax to an HMA for patients with AML (37:35) Outcomes for patients with AML experiencing disease relapse on venetoclax with an HMA; mechanisms of resistance to the venetoclax and HMA combination (39:29) Potential for venetoclax-based combinations for patients with AML eligible for intensive induction chemotherapy (43:41) Case: A woman in her mid-30s with high-risk AML who is ineligible for induction chemotherapy achieves a complete response with venetoclax and azacitidine (48:06) Perspective on the potential use of venetoclax/HMA prior to transplant (50:32) Therapeutic approach for older patients with AML harboring FLT3 and IDH mutations (53:26) Challenges associated with the use of venetoclax-based combinations (56:12) Quality-of-life impact and tolerability of venetoclax/HMA therapy (59:16) Emerging options for patients with AML harboring p53 mutations (1:01:03) Rationale for the investigation of the novel, first-in-class small molecule APR-246 in combination with azacitidine for patients with AML with TP53 mutations (1:03:30) Activity and tolerability of APR-246 in AML (1:05:53) CME information and select publications

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