How to Make a Neuron and How Pioneer Factors May Find Their Targets

published 2 weeks ago by UCTV

Marius Wernig, MD, PhD, discusses how his lab has worked to convert non-neuronal cell types (lymphocytes, pluripotent stem cells, fibroblasts, hepatocytes, lymphocytes) to neurons. The lab is now working on identifying the molecular mechanisms underlying induced lineage fate changes, the phenotypic consequences of disease-causing mutations in human neurons and other neural lineages. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Professional Medical Education] [Show ID: 35063]

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