Chronic Lymphocytic Lymphoma | Jennifer Woyach, MD

published 4 weeks ago by Dr Neil Love

Chronic Lymphocytic Lymphoma, Issue 2, 2019 — Part 2: Our interview with Dr Woyach highlights the following topics as well as cases from her practice: Recent data and evolution of the front-line treatment paradigm for patients with CLL (00:00) Evaluation of MRD and implications for therapy (03:50) Efficacy and tolerability of first-line regimens for CLL (06:14) Perspective on the role of chemoimmunotherapy for patients with CLL (08:41) Case: A woman in her mid-70s experiences a dramatic response after receiving ibrutinib as first-line therapy for CLL (10:48) Bleeding and arthralgias associated with ibrutinib (12:14) Rates of discontinuation and the role of dose reduction to mitigate side effects in patients receiving ibrutinib (14:45) Incidence and management of opportunistic infections during ibrutinib treatment (18:11) Role of chimeric antigen receptor (CAR) T-cell therapy in CLL; effect of ibrutinib on CAR T-cell generation and efficacy (21:54) Case: A man in his late 60s with CLL receives acalabrutinib on a clinical trial after developing atrial fibrillation on ibrutinib therapy (24:01) Therapeutic approach for patients who develop resistance to BTK inhibitors (27:19) Understanding the C481S mutation as a mechanism of resistance to ibrutinib and acalabrutinib (30:47) Targeting the C481S mutation to overcome resistance to BTK inhibitors (32:06) Case: A woman in her mid-60s with del(17p) CLL and no IGHV mutation receives venetoclax after disease progression on multiple lines of therapy (36:11) Prophylactic measures to prevent venetoclax-associated tumor lysis syndrome (38:25) Emerging data with the combination of ibrutinib and venetoclax for CLL (40:04) Activity and tolerability of PI3 kinase inhibitors for patients with CLL (44:17) Acalabrutinib with obinutuzumab for treatment-naïve and relapsed/refractory CLL (47:51) Incidence and spectrum of second cancers among patients with CLL receiving BTK inhibitors (49:51) Case: A man in his early 70s develops RT to DLBCL after receiving ibrutinib as first-line therapy for CLL (51:00) Prognosis and management of RT (53:38) Role of immune checkpoint inhibitors and CAR T-cell therapy in the management of RT (56:37) Ongoing Phase III EA9161 and Alliance A041702 studies evaluating the addition of venetoclax to ibrutinib with obinutuzumab for patients with CLL (59:21) CME information and select publications  

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